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phenobarbital raises toxicity of ifosfamide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. CYP3A4 inducers could boost the metabolism of ifosfamide to its active alkylating metabolites.Utilization in Pregnancy. Barbiturates can result in fetal problems when administered to the Expecting female. Retrospective, situati